Drug interactions
Amphotericin b + Corticotropin
Severity: Moderate
Amphotericin b and Corticotropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both amphotericin B and corticotropin promote potassium loss. Together they can cause severe hypokalemia, which may lead to arrhythmias and muscle weakness, and may be worsened by cardiac glycosides.
What this interaction means in plain words
Amphotericin b and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Corticotropin belongs to Endocrine.
Why it happens
Additive renal potassium wasting (amphotericin tubular effect plus mineralocorticoid effect of corticotropin).
What to do
Monitor serum potassium and cardiac status, and supplement potassium as needed. Check magnesium too.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Corticotropin
- Alogliptin-metformin + Corticotropin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Corticotropin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Corticotropin Moderate
- Atenolol-chlorthalidone + Corticotropin Moderate
- Atracurium + Corticotropin Moderate
- Azilsartan-chlorthalidone + Corticotropin Moderate
Frequently asked questions
Can I take Amphotericin b with Corticotropin?
MediHelp rates the interaction as moderate. Amphotericin b and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both amphotericin B and corticotropin promote potassium loss. Together they can cause severe hypokalemia, which may lead to arrhythmias and muscle weakness, and may be worsened by cardiac glycosides.
How serious is the interaction between Amphotericin b and Corticotropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and cardiac status, and supplement potassium as needed. Check magnesium too.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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