Drug interactions
Amphotericin b + Pancuronium
Severity: Moderate
Amphotericin b and Pancuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B-induced hypokalemia may enhance non-depolarising neuromuscular blockade by pancuronium. This may prolong paralysis and delay respiratory recovery.
What this interaction means in plain words
Amphotericin b and Pancuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Pancuronium belongs to Musculoskeletal.
Why it happens
Amphotericin-induced hypokalemia enhances the effect of non-depolarising neuromuscular blockers.
What to do
Correct potassium and magnesium before use and monitor neuromuscular blockade with train-of-four. Reduce the pancuronium dose as needed and ensure ventilatory support until full recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Pancuronium
Frequently asked questions
Can I take Amphotericin b with Pancuronium?
MediHelp rates the interaction as moderate. Amphotericin b and Pancuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B-induced hypokalemia may enhance non-depolarising neuromuscular blockade by pancuronium. This may prolong paralysis and delay respiratory recovery.
How serious is the interaction between Amphotericin b and Pancuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before use and monitor neuromuscular blockade with train-of-four. Reduce the pancuronium dose as needed and ensure ventilatory support until full recovery.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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