Drug interactions
Amphotericin b + Vancomycin
Severity: Moderate
Amphotericin b and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney, and combined use increases the risk of acute kidney injury. Reduced renal function may in turn raise vancomycin levels.
What this interaction means in plain words
Amphotericin b and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Vancomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity.
What to do
Monitor serum creatinine and vancomycin trough or AUC-guided levels, and maintain hydration. Adjust vancomycin dosing to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Amphotericin b with Vancomycin?
MediHelp rates the interaction as moderate. Amphotericin b and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney, and combined use increases the risk of acute kidney injury. Reduced renal function may in turn raise vancomycin levels.
How serious is the interaction between Amphotericin b and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and vancomycin trough or AUC-guided levels, and maintain hydration. Adjust vancomycin dosing to renal function.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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