Drug interactions
Amphotericin b + Vecuronium
Severity: Moderate
Amphotericin b and Vecuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B-related hypokalemia and hypomagnesemia can potentiate and prolong neuromuscular blockade by vecuronium. This may delay recovery of spontaneous breathing after surgery or in the ICU.
What this interaction means in plain words
Amphotericin b and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Vecuronium belongs to Musculoskeletal.
Why it happens
Indirect potentiation of non-depolarizing neuromuscular blockade through amphotericin B-induced electrolyte depletion.
What to do
Correct potassium and magnesium before neuromuscular blockade and monitor them throughout. Use train-of-four monitoring and titrate vecuronium to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Vecuronium
Frequently asked questions
Can I take Amphotericin b with Vecuronium?
MediHelp rates the interaction as moderate. Amphotericin b and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B-related hypokalemia and hypomagnesemia can potentiate and prolong neuromuscular blockade by vecuronium. This may delay recovery of spontaneous breathing after surgery or in the ICU.
How serious is the interaction between Amphotericin b and Vecuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before neuromuscular blockade and monitor them throughout. Use train-of-four monitoring and titrate vecuronium to effect.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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