Drug interactions
Amphotericin b + Voclosporin
Severity: Major
Amphotericin b and Voclosporin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can reduce renal function, and voclosporin causes dose-related nephrotoxicity and hyperkalemia. Using them together raises the risk of acute kidney injury and electrolyte disturbances.
What this interaction means in plain words
Amphotericin b and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity from amphotericin tubular toxicity and calcineurin-inhibitor afferent arteriolar vasoconstriction.
What to do
Avoid the combination where possible, or monitor eGFR, creatinine and potassium closely. Reduce or interrupt voclosporin if renal function worsens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Amphotericin b with Voclosporin?
MediHelp rates the interaction as major. Amphotericin b and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can reduce renal function, and voclosporin causes dose-related nephrotoxicity and hyperkalemia. Using them together raises the risk of acute kidney injury and electrolyte disturbances.
How serious is the interaction between Amphotericin b and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor eGFR, creatinine and potassium closely. Reduce or interrupt voclosporin if renal function worsens.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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