Drug interactions
Amphotericin b + Zidovudine
Severity: Moderate
Amphotericin b and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause bone marrow suppression, and amphotericin B may also cause renal impairment and anemia. Together they may increase hematologic toxicity, especially in patients with advanced HIV.
What this interaction means in plain words
Amphotericin b and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Zidovudine belongs to Anti Virals.
Why it happens
Additive myelosuppressive effects, with possible added renal impairment from amphotericin B.
What to do
Monitor complete blood counts and renal function frequently. Reduce the zidovudine dose or switch therapy if significant anemia or neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Frequently asked questions
Can I take Amphotericin b with Zidovudine?
MediHelp rates the interaction as moderate. Amphotericin b and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause bone marrow suppression, and amphotericin B may also cause renal impairment and anemia. Together they may increase hematologic toxicity, especially in patients with advanced HIV.
How serious is the interaction between Amphotericin b and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function frequently. Reduce the zidovudine dose or switch therapy if significant anemia or neutropenia occurs.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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