Drug reference
cisplatin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Oncology (Alkylating Agents)
Mechanism of action
Platinum coordination compound that inhibits DNA synthesis; cross-links and denatures strands of DNA; disrupts DNA function by covalently binding to DNA bases; can also produce DNA intrastrand cross-linking and breakage. Not a true alkylating agent.
Common side effects
- Alopecia
- Vomiting
- Nausea
- Anaphylaxis
- Myelosuppression
- Nephrotoxicity
- Ototoxicity, especially in children
Known interactions (1)
- cisplatin + omeprazole Moderate
Related conditions
Frequently asked questions
What drug class is cisplatin?
cisplatin belongs to: Oncology.
How does cisplatin work?
Platinum coordination compound that inhibits DNA synthesis; cross-links and denatures strands of DNA; disrupts DNA function by covalently binding to DNA bases; can also produce DNA intrastrand cross-linking and breakage. Not a true alkylating agent.
What are the common side effects of cisplatin?
Alopecia, Vomiting, Nausea, Anaphylaxis, Myelosuppression, Nephrotoxicity, Ototoxicity, especially in children
Which drugs interact with cisplatin?
omeprazole
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