Drug interactions
Bacitracin + Cisplatin
Severity: Major
Bacitracin and Cisplatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic bacitracin (parenteral) is markedly nephrotoxic, and cisplatin is nephrotoxic and ototoxic. Together they raise the risk of acute kidney injury and increased cisplatin exposure.
What this interaction means in plain words
Bacitracin and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin belongs to Miscellaneous; Cisplatin belongs to Oncology.
Why it happens
Additive nephrotoxicity from proximal tubular injury.
What to do
Avoid concurrent systemic bacitracin and choose a non-nephrotoxic antibiotic. If unavoidable, monitor serum creatinine and electrolytes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Other interactions of Bacitracin
- Bacitracin + Cidofovir Contraindicated
- Adefovir + Bacitracin Major
- Aldesleukin + Bacitracin Major
- Amikacin + Bacitracin Major
- Bacitracin + Carboplatin Major
- Bacitracin + Colistin Major
Frequently asked questions
Can I take Bacitracin with Cisplatin?
MediHelp rates the interaction as major. Bacitracin and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic bacitracin (parenteral) is markedly nephrotoxic, and cisplatin is nephrotoxic and ototoxic. Together they raise the risk of acute kidney injury and increased cisplatin exposure.
How serious is the interaction between Bacitracin and Cisplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent systemic bacitracin and choose a non-nephrotoxic antibiotic. If unavoidable, monitor serum creatinine and electrolytes closely.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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