Drug interactions
Amphotericin b deoxycholate + Oxaliplatin
Severity: Moderate
Amphotericin b deoxycholate and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B deoxycholate commonly causes kidney injury and electrolyte loss. Oxaliplatin is renally eliminated, so impaired function may raise exposure and toxicity, although oxaliplatin itself is less nephrotoxic than other platinum drugs.
What this interaction means in plain words
Amphotericin b deoxycholate and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amphotericin nephrotoxicity may reduce oxaliplatin clearance, and electrolyte disturbances can compound toxicity.
What to do
Prefer a lipid amphotericin formulation or alternative antifungal if feasible. Monitor creatinine, potassium and magnesium, and review oxaliplatin dosing if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphotericin b deoxycholate and Oxaliplatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Amphotericin b deoxycholate with Oxaliplatin?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B deoxycholate commonly causes kidney injury and electrolyte loss. Oxaliplatin is renally eliminated, so impaired function may raise exposure and toxicity, although oxaliplatin itself is less nephrotoxic than other platinum drugs.
How serious is the interaction between Amphotericin b deoxycholate and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a lipid amphotericin formulation or alternative antifungal if feasible. Monitor creatinine, potassium and magnesium, and review oxaliplatin dosing if renal function declines.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
