Drug interactions
Amphotericin b deoxycholate + Succinylcholine
Severity: Minor
Amphotericin b deoxycholate and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B deoxycholate causes hypokalemia and may alter neuromuscular sensitivity. Its effect on the depolarizing blocker succinylcholine is unpredictable and not well documented.
What this interaction means in plain words
Amphotericin b deoxycholate and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Amphotericin-induced hypokalemia may alter neuromuscular blockade; the effect on depolarizing agents is not well established.
What to do
Check and correct potassium and magnesium before anesthesia, and monitor neuromuscular function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Succinylcholine
Frequently asked questions
Can I take Amphotericin b deoxycholate with Succinylcholine?
MediHelp rates the interaction as minor. Amphotericin b deoxycholate and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amphotericin B deoxycholate causes hypokalemia and may alter neuromuscular sensitivity. Its effect on the depolarizing blocker succinylcholine is unpredictable and not well documented.
How serious is the interaction between Amphotericin b deoxycholate and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before anesthesia, and monitor neuromuscular function.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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