Drug interactions
Amphotericin b deoxycholate + Tacrolimus
Severity: Major
Amphotericin b deoxycholate and Tacrolimus: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and combining them can cause additive kidney injury and electrolyte disturbances such as hypokalemia and hypomagnesemia. Tacrolimus toxicity may follow if renal function declines.
What this interaction means in plain words
Amphotericin b deoxycholate and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity from calcineurin-inhibitor afferent vasoconstriction and amphotericin tubular toxicity.
What to do
Prefer a lipid amphotericin formulation or an alternative antifungal if possible. Monitor creatinine, electrolytes and tacrolimus trough levels closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Amphotericin b deoxycholate with Tacrolimus?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and combining them can cause additive kidney injury and electrolyte disturbances such as hypokalemia and hypomagnesemia. Tacrolimus toxicity may follow if renal function declines.
How serious is the interaction between Amphotericin b deoxycholate and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a lipid amphotericin formulation or an alternative antifungal if possible. Monitor creatinine, electrolytes and tacrolimus trough levels closely.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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