Drug interactions
Amphotericin b phospholipid complex + Oxaliplatin
Severity: Moderate
Amphotericin b phospholipid complex and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B is nephrotoxic and causes electrolyte losses, and oxaliplatin may add to renal stress. Infusion reactions such as bronchospasm and hypotension may also be additive.
What this interaction means in plain words
Amphotericin b phospholipid complex and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity and electrolyte disturbance; mechanism for infusion reactions is not well established.
What to do
Monitor renal function, potassium and magnesium regularly. Observe during infusions for hypotension or bronchospasm.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Amphotericin b phospholipid complex with Oxaliplatin?
MediHelp rates the interaction as moderate. Amphotericin b phospholipid complex and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B is nephrotoxic and causes electrolyte losses, and oxaliplatin may add to renal stress. Infusion reactions such as bronchospasm and hypotension may also be additive.
How serious is the interaction between Amphotericin b phospholipid complex and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, potassium and magnesium regularly. Observe during infusions for hypotension or bronchospasm.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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