Drug interactions
Eravacycline + Warfarin
Severity: Moderate
Eravacycline and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline-class antibiotics can potentiate warfarin and raise INR. Eravacycline labeling advises monitoring with anticoagulants.
What this interaction means in plain words
Eravacycline and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eravacycline belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Why it happens
Probably reduced vitamin K-producing gut flora; the mechanism is not firmly established.
What to do
Monitor INR during eravacycline therapy and reduce the warfarin dose if INR rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Eravacycline
- Amoxicillin-clavulanic acid + Eravacycline Moderate
- Amoxicillin + Eravacycline Moderate
- Ampicillin-sulbactam + Eravacycline Moderate
- Ampicillin + Eravacycline Moderate
Frequently asked questions
Can I take Eravacycline with Warfarin?
MediHelp rates the interaction as moderate. Eravacycline and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetracycline-class antibiotics can potentiate warfarin and raise INR. Eravacycline labeling advises monitoring with anticoagulants.
How serious is the interaction between Eravacycline and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR during eravacycline therapy and reduce the warfarin dose if INR rises.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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