Drug interactions
Ampicillin-sulbactam + Didanosine
Severity: Minor
Ampicillin-sulbactam and Didanosine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buffered didanosine formulations raise gastric pH, which was suggested to alter oral ampicillin absorption. Sulbactam-ampicillin is usually given parenterally, so a meaningful interaction is unlikely, and ampicillin absorption is not strongly pH dependent.
What this interaction means in plain words
Ampicillin-sulbactam and Didanosine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ampicillin-sulbactam belongs to Anti Bacterial; Didanosine belongs to Anti Virals.
Why it happens
Possible reduction in oral beta-lactam absorption from raised gastric pH, which is not well established.
What to do
No action is needed with intravenous ampicillin-sulbactam. If oral ampicillin is used, give it on an empty stomach and monitor response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin-sulbactam
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Frequently asked questions
Can I take Ampicillin-sulbactam with Didanosine?
MediHelp rates the interaction as minor. Ampicillin-sulbactam and Didanosine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Buffered didanosine formulations raise gastric pH, which was suggested to alter oral ampicillin absorption. Sulbactam-ampicillin is usually given parenterally, so a meaningful interaction is unlikely, and ampicillin absorption is not strongly pH dependent.
How serious is the interaction between Ampicillin-sulbactam and Didanosine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed with intravenous ampicillin-sulbactam. If oral ampicillin is used, give it on an empty stomach and monitor response.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
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