Drug interactions
Ampicillin-sulbactam + Spironolactone
Severity: Minor
Ampicillin-sulbactam and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Spironolactone causes potassium retention, and high doses of penicillin salts can add a potassium load if given as the potassium salt. Ampicillin is a sodium salt, so the risk is small and mainly relevant in renal impairment.
What this interaction means in plain words
Ampicillin-sulbactam and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ampicillin-sulbactam belongs to Anti Bacterial; Spironolactone belongs to Cardiovascular.
Why it happens
No well-established mechanism; possible additive effect on potassium and renal handling.
What to do
Monitor serum potassium in patients with renal impairment or other hyperkalemia risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin-sulbactam
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Ampicillin-sulbactam with Spironolactone?
MediHelp rates the interaction as minor. Ampicillin-sulbactam and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Spironolactone causes potassium retention, and high doses of penicillin salts can add a potassium load if given as the potassium salt. Ampicillin is a sodium salt, so the risk is small and mainly relevant in renal impairment.
How serious is the interaction between Ampicillin-sulbactam and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with renal impairment or other hyperkalemia risk factors.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
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