Drug interactions
Anagrelide + Clozapine
Severity: Major
Anagrelide and Clozapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and clozapine is also associated with myocarditis and tachycardia. Anagrelide can cause palpitations and arrhythmias, so combined use increases the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Anagrelide and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Clozapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and proarrhythmic effects.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combined use. Monitor the QTc during treatment, and avoid the combination in patients with other QT risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Clozapine?
MediHelp rates the interaction as major. Anagrelide and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and clozapine is also associated with myocarditis and tachycardia. Anagrelide can cause palpitations and arrhythmias, so combined use increases the risk of serious ventricular arrhythmia.
How serious is the interaction between Anagrelide and Clozapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combined use. Monitor the QTc during treatment, and avoid the combination in patients with other QT risk factors.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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