Drug interactions
Anagrelide + Fingolimod
Severity: Major
Anagrelide and Fingolimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia and can prolong QT, and anagrelide can prolong QT and cause tachyarrhythmias. Combined use raises the risk of ventricular arrhythmia including torsades de pointes.
What this interaction means in plain words
Anagrelide and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Fingolimod belongs to Central Nervous System.
Why it happens
Additive QT prolongation with bradycardia-related proarrhythmic risk.
What to do
Avoid the combination if an alternative exists; otherwise obtain a baseline ECG and monitor it, and correct electrolytes. Seek cardiology advice for patients with other QT risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Fingolimod?
MediHelp rates the interaction as major. Anagrelide and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fingolimod causes bradycardia and can prolong QT, and anagrelide can prolong QT and cause tachyarrhythmias. Combined use raises the risk of ventricular arrhythmia including torsades de pointes.
How serious is the interaction between Anagrelide and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists; otherwise obtain a baseline ECG and monitor it, and correct electrolytes. Seek cardiology advice for patients with other QT risk factors.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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