Drug interactions
Anagrelide + Methadone
Severity: Major
Anagrelide and Methadone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide can prolong the QT interval and cause tachyarrhythmias, and methadone has a well-known QT-prolonging effect. Combined use increases the risk of torsades de pointes.
What this interaction means in plain words
Anagrelide and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT interval prolongation.
What to do
Avoid if possible. If both are required, check a baseline ECG, correct potassium and magnesium, and repeat the ECG after dose changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Methadone?
MediHelp rates the interaction as major. Anagrelide and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anagrelide can prolong the QT interval and cause tachyarrhythmias, and methadone has a well-known QT-prolonging effect. Combined use increases the risk of torsades de pointes.
How serious is the interaction between Anagrelide and Methadone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If both are required, check a baseline ECG, correct potassium and magnesium, and repeat the ECG after dose changes.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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