Drug interactions
Anakinra + Denosumab
Severity: Moderate
Anakinra and Denosumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anakinra blocks IL-1 and carries a risk of serious infection, and denosumab labeling advises caution with concomitant immunosuppressants. Combined use may further increase infection risk.
What this interaction means in plain words
Anakinra and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anakinra belongs to Musculoskeletal; Denosumab belongs to Oncology.
Why it happens
Additive infection risk from IL-1 receptor blockade and RANKL inhibition; no pharmacokinetic mechanism.
What to do
Monitor for signs of infection and treat early. Interrupt therapy if a serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Azacitidine + Denosumab Moderate
- Azathioprine + Denosumab Moderate
Frequently asked questions
Can I take Anakinra with Denosumab?
MediHelp rates the interaction as moderate. Anakinra and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anakinra blocks IL-1 and carries a risk of serious infection, and denosumab labeling advises caution with concomitant immunosuppressants. Combined use may further increase infection risk.
How serious is the interaction between Anakinra and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and treat early. Interrupt therapy if a serious infection develops.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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