Drug interactions
Azacitidine + Denosumab
Severity: Moderate
Azacitidine and Denosumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Denosumab labeling warns of serious infections, including skin infections, in patients with impaired immunity. Azacitidine causes myelosuppression and neutropenia, which adds to infection risk.
What this interaction means in plain words
Azacitidine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azacitidine belongs to Oncology; Denosumab belongs to Oncology.
Why it happens
Additive infection risk: denosumab alters RANKL-mediated immune signalling, while azacitidine suppresses bone marrow function.
What to do
Monitor for signs of infection and check blood counts regularly. Treat infections promptly and reassess the need for denosumab if serious infections develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azacitidine and Denosumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azathioprine + Denosumab Moderate
Other interactions of Azacitidine
- Azacitidine + Fingolimod Major
- Azacitidine + Siponimod Major
- Azacitidine + Dichlorphenamide Moderate
- Azacitidine + Hydroxyurea Moderate
- Azacitidine + Trastuzumab Moderate
Frequently asked questions
Can I take Azacitidine with Denosumab?
MediHelp rates the interaction as moderate. Azacitidine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab labeling warns of serious infections, including skin infections, in patients with impaired immunity. Azacitidine causes myelosuppression and neutropenia, which adds to infection risk.
How serious is the interaction between Azacitidine and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts regularly. Treat infections promptly and reassess the need for denosumab if serious infections develop.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
