Drug interactions
Anastrozole + Metaxalone
Severity: Minor
Anastrozole and Metaxalone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anastrozole is not a clinically significant inhibitor of CYP3A4 at therapeutic doses, and metaxalone has multiple metabolic pathways. A meaningful increase in metaxalone exposure is unlikely.
What this interaction means in plain words
Anastrozole and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Anastrozole belongs to Oncology; Metaxalone belongs to Musculoskeletal.
Why it happens
Theoretical weak CYP3A4 inhibition; not demonstrated clinically.
What to do
No dose adjustment is required. Monitor for expected metaxalone side effects such as drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Anastrozole
- Anastrozole + Bazedoxifene / conjugated estrogens Contraindicated
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Anastrozole + Conjugated estrogens Contraindicated
- Anastrozole + Estradiol Contraindicated
- Anastrozole + Estrogens conjugated synthetic Contraindicated
- Anastrozole + Estrogens esterified Contraindicated
Frequently asked questions
Can I take Anastrozole with Metaxalone?
MediHelp rates the interaction as minor. Anastrozole and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Anastrozole is not a clinically significant inhibitor of CYP3A4 at therapeutic doses, and metaxalone has multiple metabolic pathways. A meaningful increase in metaxalone exposure is unlikely.
How serious is the interaction between Anastrozole and Metaxalone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for expected metaxalone side effects such as drowsiness.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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