Drug interactions
Anifrolumab + Warfarin
Severity: Minor
Anifrolumab and Warfarin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Type I interferon blockade could theoretically change CYP450 activity, but no effect on warfarin has been shown. Because warfarin has a narrow therapeutic index, any change could affect bleeding or clotting risk.
What this interaction means in plain words
Anifrolumab and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Anifrolumab belongs to Miscellaneous; Warfarin belongs to Cardiovascular.
Why it happens
Theoretical modulation of CYP450 expression through interferon pathway inhibition; not established clinically.
What to do
Monitor INR more closely when anifrolumab is started or stopped. Adjust warfarin dose only if INR moves out of range.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Anifrolumab and Warfarin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Anifrolumab
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Anifrolumab with Warfarin?
MediHelp rates the interaction as minor. Anifrolumab and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Type I interferon blockade could theoretically change CYP450 activity, but no effect on warfarin has been shown. Because warfarin has a narrow therapeutic index, any change could affect bleeding or clotting risk.
How serious is the interaction between Anifrolumab and Warfarin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more closely when anifrolumab is started or stopped. Adjust warfarin dose only if INR moves out of range.
What other medicines interact with Anifrolumab?
MediHelp also lists interactions of Anifrolumab with, for example, Measles mumps and rubella vaccine. The full list is on the Anifrolumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
