Drug interactions
Anthrax vaccine + Sirolimus
Severity: Moderate
Anthrax vaccine and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may reduce the antibody response to anthrax vaccine. The vaccine is non-live, so the issue is lower protection, not infection.
What this interaction means in plain words
Anthrax vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition suppresses T- and B-cell proliferation and antibody responses.
What to do
Give the vaccine if exposure risk exists and complete the schedule. Consider checking antibody response, and do not stop sirolimus solely for vaccination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Anthrax vaccine with Sirolimus?
MediHelp rates the interaction as moderate. Anthrax vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus may reduce the antibody response to anthrax vaccine. The vaccine is non-live, so the issue is lower protection, not infection.
How serious is the interaction between Anthrax vaccine and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine if exposure risk exists and complete the schedule. Consider checking antibody response, and do not stop sirolimus solely for vaccination.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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