Drug interactions
Anti-inhibitor coagulant complex + Tranexamic acid
Severity: Major
Anti-inhibitor coagulant complex and Tranexamic acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranexamic acid blocks fibrinolysis while anti-inhibitor coagulant complex (activated prothrombin complex concentrate) promotes clot formation. Together they raise the risk of thrombotic events, including venous thrombosis and myocardial infarction.
What this interaction means in plain words
Anti-inhibitor coagulant complex and Tranexamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive prothrombotic effect from antifibrinolytic action combined with a procoagulant product.
What to do
Avoid concurrent use, or give tranexamic acid no sooner than about 6 to 12 hours after the complex per labeling. Monitor for signs of thrombosis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranexamic acid
- Dienogest / estradiol valerate + Tranexamic acid Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Ethinylestradiol + Tranexamic acid Contraindicated
- Mestranol + Tranexamic acid Contraindicated
Frequently asked questions
Can I take Anti-inhibitor coagulant complex with Tranexamic acid?
MediHelp rates the interaction as major. Anti-inhibitor coagulant complex and Tranexamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tranexamic acid blocks fibrinolysis while anti-inhibitor coagulant complex (activated prothrombin complex concentrate) promotes clot formation. Together they raise the risk of thrombotic events, including venous thrombosis and myocardial infarction.
How serious is the interaction between Anti-inhibitor coagulant complex and Tranexamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use, or give tranexamic acid no sooner than about 6 to 12 hours after the complex per labeling. Monitor for signs of thrombosis.
What other medicines interact with Tranexamic acid?
MediHelp also lists interactions of Tranexamic acid with, for example, Dienogest / estradiol valerate, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel. The full list is on the Tranexamic acid page.
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