Drug interactions
Anti-thymocyte + Measles mumps rubella and varicella vaccine live
Severity: Contraindicated
Anti-thymocyte and Measles mumps rubella and varicella vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This live combination vaccine can cause serious disseminated infection with vaccine viruses in patients immunosuppressed by anti-thymocyte globulin. Vaccine response is also impaired.
What this interaction means in plain words
Anti-thymocyte and Measles mumps rubella and varicella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
T-cell depletion permits uncontrolled replication of live attenuated viruses.
What to do
Do not administer during or after anti-thymocyte globulin until immune reconstitution is confirmed. Vaccinate at least 4 weeks before therapy if feasible.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
- Anti-thymocyte + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Anti-thymocyte with Measles mumps rubella and varicella vaccine live?
MediHelp rates the interaction as contraindicated. Anti-thymocyte and Measles mumps rubella and varicella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This live combination vaccine can cause serious disseminated infection with vaccine viruses in patients immunosuppressed by anti-thymocyte globulin. Vaccine response is also impaired.
How serious is the interaction between Anti-thymocyte and Measles mumps rubella and varicella vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not administer during or after anti-thymocyte globulin until immune reconstitution is confirmed. Vaccinate at least 4 weeks before therapy if feasible.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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