Drug interactions
Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal
Severity: Contraindicated
Anti-thymocyte and Influenza virus vaccine quadrivalent intranasal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine contains live attenuated virus, which could cause vaccine-strain infection in a patient profoundly immunosuppressed by anti-thymocyte globulin. The immune response to it is also likely to be poor.
What this interaction means in plain words
Anti-thymocyte and Influenza virus vaccine quadrivalent intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Profound T-cell depletion allows replication of live attenuated virus and impairs the immune response.
What to do
Do not give the live intranasal vaccine; use an inactivated injectable influenza vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
- Anti-thymocyte + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Anti-thymocyte with Influenza virus vaccine quadrivalent intranasal?
MediHelp rates the interaction as contraindicated. Anti-thymocyte and Influenza virus vaccine quadrivalent intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus, which could cause vaccine-strain infection in a patient profoundly immunosuppressed by anti-thymocyte globulin. The immune response to it is also likely to be poor.
How serious is the interaction between Anti-thymocyte and Influenza virus vaccine quadrivalent intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the live intranasal vaccine; use an inactivated injectable influenza vaccine instead.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Anti-thymocyte page.
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