Drug interactions
Anti-thymocyte + Cyclosporine
Severity: Moderate
Anti-thymocyte and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithymocyte globulin is routinely combined with cyclosporine in transplantation and aplastic anemia protocols, but the combined immunosuppression raises the risk of infections and lymphoproliferative disorders. Cyclosporine adds nephrotoxicity and hypertension.
What this interaction means in plain words
Anti-thymocyte and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from T-cell depletion and calcineurin inhibition.
What to do
Use only within established protocols, with antimicrobial prophylaxis as indicated. Monitor cyclosporine trough levels, renal function and signs of infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Anti-thymocyte with Cyclosporine?
MediHelp rates the interaction as moderate. Anti-thymocyte and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithymocyte globulin is routinely combined with cyclosporine in transplantation and aplastic anemia protocols, but the combined immunosuppression raises the risk of infections and lymphoproliferative disorders. Cyclosporine adds nephrotoxicity and hypertension.
How serious is the interaction between Anti-thymocyte and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only within established protocols, with antimicrobial prophylaxis as indicated. Monitor cyclosporine trough levels, renal function and signs of infection.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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