Drug interactions
Anti-thymocyte + Diphtheria and tetanus toxoids / acellular pertussis vaccine
Severity: Moderate
Anti-thymocyte and Diphtheria and tetanus toxoids / acellular pertussis vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anti-thymocyte globulin depletes T cells and can blunt the response to this non-live vaccine. The vaccine is not harmful, but protection may be inadequate.
What this interaction means in plain words
Anti-thymocyte and Diphtheria and tetanus toxoids / acellular pertussis vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
T-lymphocyte depletion impairs the immune response to the vaccine antigens.
What to do
Vaccinate before immunosuppression when possible, or defer until immune recovery. Consider checking antibody titres and revaccinating if given during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Anti-thymocyte with Diphtheria and tetanus toxoids / acellular pertussis vaccine?
MediHelp rates the interaction as moderate. Anti-thymocyte and Diphtheria and tetanus toxoids / acellular pertussis vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anti-thymocyte globulin depletes T cells and can blunt the response to this non-live vaccine. The vaccine is not harmful, but protection may be inadequate.
How serious is the interaction between Anti-thymocyte and Diphtheria and tetanus toxoids / acellular pertussis vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before immunosuppression when possible, or defer until immune recovery. Consider checking antibody titres and revaccinating if given during therapy.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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