Drug interactions
Anti-thymocyte + Influenza virus vaccine quadrivalent cell-cultured
Severity: Moderate
Anti-thymocyte and Influenza virus vaccine quadrivalent cell-cultured: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anti-thymocyte globulin can blunt the immune response to the inactivated cell-cultured influenza vaccine. Protection may be reduced although the vaccine itself is not harmful.
What this interaction means in plain words
Anti-thymocyte and Influenza virus vaccine quadrivalent cell-cultured can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: T-cell depletion impairs vaccine immunogenicity.
What to do
Vaccinate annually regardless, preferably before anti-thymocyte globulin or after immune recovery. Do not rely on the vaccine alone in highly immunosuppressed patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Anti-thymocyte with Influenza virus vaccine quadrivalent cell-cultured?
MediHelp rates the interaction as moderate. Anti-thymocyte and Influenza virus vaccine quadrivalent cell-cultured can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anti-thymocyte globulin can blunt the immune response to the inactivated cell-cultured influenza vaccine. Protection may be reduced although the vaccine itself is not harmful.
How serious is the interaction between Anti-thymocyte and Influenza virus vaccine quadrivalent cell-cultured?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate annually regardless, preferably before anti-thymocyte globulin or after immune recovery. Do not rely on the vaccine alone in highly immunosuppressed patients.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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