Drug interactions
Anti-thymocyte + Influenza virus vaccine quadrivalent
Severity: Moderate
Anti-thymocyte and Influenza virus vaccine quadrivalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anti-thymocyte globulin can weaken the response to inactivated influenza vaccine, leaving the patient less protected. The vaccine remains safe, and annual vaccination is still recommended in transplant recipients.
What this interaction means in plain words
Anti-thymocyte and Influenza virus vaccine quadrivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: lymphocyte depletion reduces vaccine-induced antibody production.
What to do
Still give the inactivated vaccine each season, ideally before or well after a course of anti-thymocyte globulin. Reinforce other preventive measures in the period of deepest immunosuppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Anti-thymocyte with Influenza virus vaccine quadrivalent?
MediHelp rates the interaction as moderate. Anti-thymocyte and Influenza virus vaccine quadrivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anti-thymocyte globulin can weaken the response to inactivated influenza vaccine, leaving the patient less protected. The vaccine remains safe, and annual vaccination is still recommended in transplant recipients.
How serious is the interaction between Anti-thymocyte and Influenza virus vaccine quadrivalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Still give the inactivated vaccine each season, ideally before or well after a course of anti-thymocyte globulin. Reinforce other preventive measures in the period of deepest immunosuppression.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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