Drug interactions
Anti-thymocyte + Mycophenolate
Severity: Moderate
Anti-thymocyte and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is a standard transplant immunosuppression combination, but it raises overall immunosuppression and the risk of opportunistic infections, CMV disease and malignancy. Protocols use it deliberately with defined doses.
What this interaction means in plain words
Anti-thymocyte and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression via T-cell depletion and inhibition of lymphocyte purine synthesis.
What to do
Use within a transplant protocol with antiviral and Pneumocystis prophylaxis, and monitor blood counts and infection. Reduce mycophenolate dose for leukopenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Anti-thymocyte with Mycophenolate?
MediHelp rates the interaction as moderate. Anti-thymocyte and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This is a standard transplant immunosuppression combination, but it raises overall immunosuppression and the risk of opportunistic infections, CMV disease and malignancy. Protocols use it deliberately with defined doses.
How serious is the interaction between Anti-thymocyte and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use within a transplant protocol with antiviral and Pneumocystis prophylaxis, and monitor blood counts and infection. Reduce mycophenolate dose for leukopenia.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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