Drug interactions
Anti-thymocyte + Olaparib
Severity: Moderate
Anti-thymocyte and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and anti-thymocyte globulin can cause leukopenia and thrombocytopenia. Together they may worsen cytopenias and infection risk.
What this interaction means in plain words
Anti-thymocyte and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anti-thymocyte belongs to Miscellaneous; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts frequently and interrupt or reduce olaparib for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Anti-thymocyte with Olaparib?
MediHelp rates the interaction as moderate. Anti-thymocyte and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and anti-thymocyte globulin can cause leukopenia and thrombocytopenia. Together they may worsen cytopenias and infection risk.
How serious is the interaction between Anti-thymocyte and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and interrupt or reduce olaparib for significant cytopenias.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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