Drug interactions
Anti-thymocyte + Pneumococcal vaccine heptavalent
Severity: Moderate
Anti-thymocyte and Pneumococcal vaccine heptavalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anti-thymocyte globulin can blunt the antibody response to pneumococcal conjugate vaccine. Immunosuppressed patients are at higher risk of invasive pneumococcal disease, so reduced protection is relevant.
What this interaction means in plain words
Anti-thymocyte and Pneumococcal vaccine heptavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: T-cell depletion reduces vaccine immunogenicity.
What to do
Vaccinate before therapy when possible or after immune recovery. Follow current schedules for transplant or immunocompromised patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Anti-thymocyte with Pneumococcal vaccine heptavalent?
MediHelp rates the interaction as moderate. Anti-thymocyte and Pneumococcal vaccine heptavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anti-thymocyte globulin can blunt the antibody response to pneumococcal conjugate vaccine. Immunosuppressed patients are at higher risk of invasive pneumococcal disease, so reduced protection is relevant.
How serious is the interaction between Anti-thymocyte and Pneumococcal vaccine heptavalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before therapy when possible or after immune recovery. Follow current schedules for transplant or immunocompromised patients.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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