Drug interactions
Anti-thymocyte + Typhoid vaccine live
Severity: Contraindicated
Anti-thymocyte and Typhoid vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live oral typhoid vaccine (Ty21a) contains attenuated bacteria that could cause invasive infection in a patient profoundly immunosuppressed by anti-thymocyte globulin. The vaccine response may also be poor.
What this interaction means in plain words
Anti-thymocyte and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Impaired immunity allows replication of live attenuated bacteria.
What to do
Do not give the live oral vaccine; use the inactivated Vi polysaccharide injection instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Anti-thymocyte with Typhoid vaccine live?
MediHelp rates the interaction as contraindicated. Anti-thymocyte and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live oral typhoid vaccine (Ty21a) contains attenuated bacteria that could cause invasive infection in a patient profoundly immunosuppressed by anti-thymocyte globulin. The vaccine response may also be poor.
How serious is the interaction between Anti-thymocyte and Typhoid vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the live oral vaccine; use the inactivated Vi polysaccharide injection instead.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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