Drug interactions
Antithrombin alfa + Estradiol
Severity: Major
Antithrombin alfa and Estradiol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens promote a prothrombotic state, which may counteract the anticoagulant effect of antithrombin and raise thrombosis risk.
What this interaction means in plain words
Antithrombin alfa and Estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Estradiol increases hepatic synthesis of clotting factors and reduces natural anticoagulant activity, opposing antithrombin.
What to do
Review the need for estrogen in patients requiring antithrombin; if used, monitor antithrombin activity and for thrombotic events.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
- Estradiol + Fosphenytoin Major
Frequently asked questions
Can I take Antithrombin alfa with Estradiol?
MediHelp rates the interaction as major. Antithrombin alfa and Estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Estrogens promote a prothrombotic state, which may counteract the anticoagulant effect of antithrombin and raise thrombosis risk.
How serious is the interaction between Antithrombin alfa and Estradiol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the need for estrogen in patients requiring antithrombin; if used, monitor antithrombin activity and for thrombotic events.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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