Drug reference
estradiol
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Endocrine (Gonadal Hormones)
Mechanism of action
Endogenous estrogen; reduces release of gonadotropin-releasing hormone and luteinizing hormone-releasing hormone from hypothalamus; reduces gonadotropin release from pituitary; increases synthesis of DNA, RNA, and various proteins in target tissues
Common side effects
- Abdominal cramping
- Anxiety
- Bloating
- Amenorrhea
- Breast tenderness
- Breast enlargement
- Breakthrough bleeding
Known interactions (6)
- anastrozole + estradiol Contraindicated
- argatroban + estradiol Moderate
- dalteparin + estradiol Moderate
- enoxaparin + estradiol Moderate
- estradiol + fondaparinux Moderate
- estradiol + heparin Moderate
Related conditions
Frequently asked questions
What drug class is estradiol?
estradiol belongs to: Endocrine.
How does estradiol work?
Endogenous estrogen; reduces release of gonadotropin-releasing hormone and luteinizing hormone-releasing hormone from hypothalamus; reduces gonadotropin release from pituitary; increases synthesis of DNA, RNA, and various proteins in target tissues
What are the common side effects of estradiol?
Abdominal cramping, Anxiety, Bloating, Amenorrhea, Breast tenderness, Breast enlargement, Breakthrough bleeding
Which drugs interact with estradiol?
anastrozole, argatroban, dalteparin, enoxaparin, fondaparinux, heparin
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