Drug interactions
Antithrombin iii + Estradiol
Severity: Major
Antithrombin iii and Estradiol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens increase thrombotic tendency and may blunt the effect of antithrombin III replacement, increasing the risk of thromboembolism.
What this interaction means in plain words
Antithrombin iii and Estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Estradiol raises procoagulant factor levels and lowers antithrombin activity, pharmacodynamically opposing therapy.
What to do
Avoid estrogen in patients needing antithrombin treatment where possible. If used, monitor antithrombin activity and for thrombosis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Estradiol + Exemestane Major
- Estradiol + Fosphenytoin Major
Frequently asked questions
Can I take Antithrombin iii with Estradiol?
MediHelp rates the interaction as major. Antithrombin iii and Estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Estrogens increase thrombotic tendency and may blunt the effect of antithrombin III replacement, increasing the risk of thromboembolism.
How serious is the interaction between Antithrombin iii and Estradiol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid estrogen in patients needing antithrombin treatment where possible. If used, monitor antithrombin activity and for thrombosis.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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