Drug interactions
Antithrombin alfa + Fondaparinux
Severity: Moderate
Antithrombin alfa and Fondaparinux: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fondaparinux acts by binding antithrombin, and recombinant antithrombin raises the amount of available cofactor, which may amplify its anticoagulant effect. This can increase bleeding risk.
What this interaction means in plain words
Antithrombin alfa and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased antithrombin availability enhances the antithrombin-dependent factor Xa inhibition produced by fondaparinux.
What to do
Monitor for bleeding and consider anti-Xa monitoring calibrated for fondaparinux; reassess the fondaparinux dose while antithrombin is given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Antithrombin alfa with Fondaparinux?
MediHelp rates the interaction as moderate. Antithrombin alfa and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fondaparinux acts by binding antithrombin, and recombinant antithrombin raises the amount of available cofactor, which may amplify its anticoagulant effect. This can increase bleeding risk.
How serious is the interaction between Antithrombin alfa and Fondaparinux?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider anti-Xa monitoring calibrated for fondaparinux; reassess the fondaparinux dose while antithrombin is given.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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