Drug interactions
Antithrombin alfa + Mefenamic acid
Severity: Moderate
Antithrombin alfa and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin potentiates heparin-type anticoagulation, and mefenamic acid impairs platelet function and can injure the gastric mucosa. Together they may increase the risk of bleeding.
What this interaction means in plain words
Antithrombin alfa and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: antithrombin enhances inhibition of coagulation factors while NSAIDs inhibit platelet aggregation.
What to do
Monitor for bleeding and coagulation parameters, and avoid the NSAID where an alternative analgesic is possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Antithrombin alfa and Mefenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Antithrombin alfa with Mefenamic acid?
MediHelp rates the interaction as moderate. Antithrombin alfa and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin potentiates heparin-type anticoagulation, and mefenamic acid impairs platelet function and can injure the gastric mucosa. Together they may increase the risk of bleeding.
How serious is the interaction between Antithrombin alfa and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters, and avoid the NSAID where an alternative analgesic is possible.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
