Drug interactions
Antithrombin alfa + Nabumetone
Severity: Moderate
Antithrombin alfa and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin potentiates heparin-type anticoagulation, and nabumetone inhibits platelet function and can injure the gastric mucosa. Together they may raise the risk of bleeding, particularly gastrointestinal bleeding.
What this interaction means in plain words
Antithrombin alfa and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect on hemostasis: antithrombin enhances coagulation inhibition while NSAID-mediated COX inhibition impairs platelet aggregation and mucosal integrity.
What to do
Monitor for signs of bleeding and coagulation parameters during antithrombin therapy. Consider avoiding the NSAID or using a gastroprotective agent when co-therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Antithrombin alfa with Nabumetone?
MediHelp rates the interaction as moderate. Antithrombin alfa and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin potentiates heparin-type anticoagulation, and nabumetone inhibits platelet function and can injure the gastric mucosa. Together they may raise the risk of bleeding, particularly gastrointestinal bleeding.
How serious is the interaction between Antithrombin alfa and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and coagulation parameters during antithrombin therapy. Consider avoiding the NSAID or using a gastroprotective agent when co-therapy is needed.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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