Drug interactions
Antithrombin alfa + Piroxicam
Severity: Moderate
Antithrombin alfa and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin potentiates heparin-type anticoagulation, and piroxicam inhibits platelet function and can injure the gastric mucosa. Together they raise the risk of bleeding, especially from the gastrointestinal tract.
What this interaction means in plain words
Antithrombin alfa and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment: antithrombin inhibits coagulation factors while piroxicam impairs platelet aggregation via COX-1 inhibition.
What to do
Monitor for bleeding and follow coagulation parameters such as anti-Xa or aPTT. Prefer a non-NSAID analgesic such as paracetamol where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Antithrombin alfa with Piroxicam?
MediHelp rates the interaction as moderate. Antithrombin alfa and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin potentiates heparin-type anticoagulation, and piroxicam inhibits platelet function and can injure the gastric mucosa. Together they raise the risk of bleeding, especially from the gastrointestinal tract.
How serious is the interaction between Antithrombin alfa and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and follow coagulation parameters such as anti-Xa or aPTT. Prefer a non-NSAID analgesic such as paracetamol where possible.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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