Drug interactions
Antithrombin iii + Dalteparin
Severity: Moderate
Antithrombin iii and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III concentrate enhances the activity of heparins such as dalteparin, which act through antithrombin. This can increase anticoagulant effect and bleeding risk.
What this interaction means in plain words
Antithrombin iii and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effect, since dalteparin catalyzes antithrombin-mediated inhibition of factor Xa and replaced antithrombin increases that activity.
What to do
Monitor anti-Xa activity and signs of bleeding, and reduce the dalteparin dose if anticoagulation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Antithrombin iii with Dalteparin?
MediHelp rates the interaction as moderate. Antithrombin iii and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III concentrate enhances the activity of heparins such as dalteparin, which act through antithrombin. This can increase anticoagulant effect and bleeding risk.
How serious is the interaction between Antithrombin iii and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor anti-Xa activity and signs of bleeding, and reduce the dalteparin dose if anticoagulation is excessive.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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