Drug interactions
Antithrombin iii + Gemcitabine
Severity: Moderate
Antithrombin iii and Gemcitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemcitabine can cause thrombocytopenia, and antithrombin III potentiates heparin-mediated anticoagulation. Together they may increase the risk of bleeding.
What this interaction means in plain words
Antithrombin iii and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic additive bleeding risk from chemotherapy-induced thrombocytopenia and enhanced anticoagulation.
What to do
Monitor platelet counts and coagulation parameters, and watch for bleeding. Adjust or hold anticoagulant therapy if platelets fall significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemcitabine
Frequently asked questions
Can I take Antithrombin iii with Gemcitabine?
MediHelp rates the interaction as moderate. Antithrombin iii and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemcitabine can cause thrombocytopenia, and antithrombin III potentiates heparin-mediated anticoagulation. Together they may increase the risk of bleeding.
How serious is the interaction between Antithrombin iii and Gemcitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and coagulation parameters, and watch for bleeding. Adjust or hold anticoagulant therapy if platelets fall significantly.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
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