Drug interactions
Antithrombin iii + Mefenamic acid
Severity: Moderate
Antithrombin iii and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III augments anticoagulation, while mefenamic acid reduces platelet function and can cause gastrointestinal mucosal injury. The combination can raise bleeding risk.
What this interaction means in plain words
Antithrombin iii and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects: antithrombin enhances inhibition of clotting factors and NSAIDs impair platelet aggregation.
What to do
Monitor for bleeding and relevant coagulation tests, and prefer a non-NSAID analgesic such as paracetamol when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Antithrombin iii with Mefenamic acid?
MediHelp rates the interaction as moderate. Antithrombin iii and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III augments anticoagulation, while mefenamic acid reduces platelet function and can cause gastrointestinal mucosal injury. The combination can raise bleeding risk.
How serious is the interaction between Antithrombin iii and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and relevant coagulation tests, and prefer a non-NSAID analgesic such as paracetamol when possible.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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