Drug interactions
Antithrombin iii + Nabumetone
Severity: Moderate
Antithrombin iii and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III enhances inhibition of clotting factors, especially when given with heparin, while nabumetone reduces platelet function and can cause GI mucosal injury. The combination may increase the chance of clinically significant bleeding.
What this interaction means in plain words
Antithrombin iii and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect on hemostasis: enhanced coagulation factor inhibition plus NSAID-induced platelet dysfunction and mucosal injury.
What to do
Monitor for bleeding and coagulation tests while on antithrombin therapy. Avoid the NSAID where possible, or add gastroprotection if it is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Antithrombin iii with Nabumetone?
MediHelp rates the interaction as moderate. Antithrombin iii and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III enhances inhibition of clotting factors, especially when given with heparin, while nabumetone reduces platelet function and can cause GI mucosal injury. The combination may increase the chance of clinically significant bleeding.
How serious is the interaction between Antithrombin iii and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation tests while on antithrombin therapy. Avoid the NSAID where possible, or add gastroprotection if it is required.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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