Drug interactions
Antithrombin iii + Piroxicam
Severity: Moderate
Antithrombin iii and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III enhances inhibition of thrombin and factor Xa, while piroxicam impairs platelet function and can cause gastric erosions. The combination increases the chance of clinically significant bleeding.
What this interaction means in plain words
Antithrombin iii and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment through anticoagulant activity plus NSAID-induced platelet inhibition.
What to do
Monitor for bleeding and coagulation parameters, and use paracetamol or another non-NSAID analgesic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Antithrombin iii and Piroxicam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Antithrombin iii with Piroxicam?
MediHelp rates the interaction as moderate. Antithrombin iii and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III enhances inhibition of thrombin and factor Xa, while piroxicam impairs platelet function and can cause gastric erosions. The combination increases the chance of clinically significant bleeding.
How serious is the interaction between Antithrombin iii and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters, and use paracetamol or another non-NSAID analgesic if feasible.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
