Drug interactions
Antithymocyte globulin equine + Sirolimus
Severity: Moderate
Antithymocyte globulin equine and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are routinely used together in transplant regimens, but combined immunosuppression increases the risk of opportunistic infections, lymphoproliferative disorders and cytopenias. The combination is planned and managed rather than avoided.
What this interaction means in plain words
Antithymocyte globulin equine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression through T-cell depletion and mTOR inhibition.
What to do
Use under transplant specialist supervision with antimicrobial prophylaxis and monitoring of blood counts and infection. Adjust sirolimus dosing by trough levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Antithymocyte globulin equine with Sirolimus?
MediHelp rates the interaction as moderate. Antithymocyte globulin equine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are routinely used together in transplant regimens, but combined immunosuppression increases the risk of opportunistic infections, lymphoproliferative disorders and cytopenias. The combination is planned and managed rather than avoided.
How serious is the interaction between Antithymocyte globulin equine and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use under transplant specialist supervision with antimicrobial prophylaxis and monitoring of blood counts and infection. Adjust sirolimus dosing by trough levels.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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