Drug interactions
Antithymocyte globulin rabbit + Mycophenolate mofetil
Severity: Major
Antithymocyte globulin rabbit and Mycophenolate mofetil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabbit antithymocyte globulin causes profound T-cell depletion, and combined with mycophenolate the degree of immunosuppression is increased. Infection and malignancy risk rise, although the combination is standard in many transplant regimens.
What this interaction means in plain words
Antithymocyte globulin rabbit and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from T-cell depletion and inhibition of lymphocyte proliferation.
What to do
Use only within established transplant protocols, with antiviral and antimicrobial prophylaxis and monitoring of white cell counts and infections.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Antithymocyte globulin rabbit with Mycophenolate mofetil?
MediHelp rates the interaction as major. Antithymocyte globulin rabbit and Mycophenolate mofetil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rabbit antithymocyte globulin causes profound T-cell depletion, and combined with mycophenolate the degree of immunosuppression is increased. Infection and malignancy risk rise, although the combination is standard in many transplant regimens.
How serious is the interaction between Antithymocyte globulin rabbit and Mycophenolate mofetil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only within established transplant protocols, with antiviral and antimicrobial prophylaxis and monitoring of white cell counts and infections.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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