Drug interactions
Measles vaccine + Mycophenolate mofetil
Severity: Contraindicated
Measles vaccine and Mycophenolate mofetil: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Measles vaccine is live attenuated and can cause disseminated vaccine-strain infection in patients with significant immunosuppression. Mycophenolate may also reduce the immune response.
What this interaction means in plain words
Measles vaccine and Mycophenolate mofetil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Impaired T and B cell function allows uncontrolled replication of live attenuated virus.
What to do
Avoid the vaccine during mycophenolate therapy. Give it at least 4 weeks before starting treatment if possible, and use immunoglobulin prophylaxis after exposure.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Mycophenolate mofetil + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Measles vaccine with Mycophenolate mofetil?
MediHelp rates the interaction as contraindicated. Measles vaccine and Mycophenolate mofetil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Measles vaccine is live attenuated and can cause disseminated vaccine-strain infection in patients with significant immunosuppression. Mycophenolate may also reduce the immune response.
How serious is the interaction between Measles vaccine and Mycophenolate mofetil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the vaccine during mycophenolate therapy. Give it at least 4 weeks before starting treatment if possible, and use immunoglobulin prophylaxis after exposure.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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