Drug interactions
Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil
Severity: Contraindicated
Influenza virus vaccine quadrivalent intranasal and Mycophenolate mofetil: contraindicated interaction.
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For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine contains live attenuated virus, which can replicate in patients taking mycophenolate and cause vaccine-strain disease. Its efficacy may also be reduced. It is contraindicated in significantly immunosuppressed patients.
What this interaction means in plain words
Influenza virus vaccine quadrivalent intranasal and Mycophenolate mofetil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Impaired cellular and humoral immunity from mycophenolate permits uncontrolled replication of live attenuated virus.
What to do
Do not use the live intranasal vaccine; give an inactivated injectable influenza vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
- Mycophenolate mofetil + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent intranasal with Mycophenolate mofetil?
MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Mycophenolate mofetil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus, which can replicate in patients taking mycophenolate and cause vaccine-strain disease. Its efficacy may also be reduced. It is contraindicated in significantly immunosuppressed patients.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Mycophenolate mofetil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the live intranasal vaccine; give an inactivated injectable influenza vaccine instead.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Measles mumps and rubella vaccine live. The full list is on the Mycophenolate mofetil page.
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